منابع مشابه
Apoptotic Pathways: Ten Minutes to Dead
For more than a decade, it has been apparent that apoptosis and other forms of cell death are often controlled at one or more crucial steps involving the mitochondria. Recent findings, including an elegant investigation in a recent issue of Cell (Hao et al., 2005), have helped to elucidate fundamental aspects of this involvement while raising puzzling new questions about mitochondrial routes to...
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Procaspase aggregation is mediated by the binding of adaptor molecules to protein interaction domains in the prodomains of some caspases. Two general types of interaction domains have been identified. Procas-pases-8 and-10 each contain two tandem death effector domains (DEDs), while procaspases-1,-2,-4,-5, and-9 Introduction contain caspase recruitment domains (CARDs). In each Nearly all physio...
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Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution o...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.05.019